diff --git a/README.md b/README.md
index 16426399..2954d242 100644
--- a/README.md
+++ b/README.md
@@ -93,6 +93,7 @@ Some examples require extra dependencies. See each sample's directory for specif
   This contains two samples, one sending messages to an existing workflow and a second that creates a workflow through Nexus
   and sends messages to it.
 * [nexus_multiple_args](nexus_multiple_args) - Map a Nexus operation to a handler workflow that takes multiple arguments.
+* [nexus_standalone_activity](nexus_standalone_activity) - Back a Nexus operation with a standalone Activity.
 * [nexus_standalone_operations](nexus_standalone_operations) - Execute Nexus operations directly from client code,
 without wrapping them in a workflow.
 * [open_telemetry](open_telemetry) - Trace workflows with OpenTelemetry.
diff --git a/nexus_standalone_activity/README.md b/nexus_standalone_activity/README.md
new file mode 100644
index 00000000..1f795424
--- /dev/null
+++ b/nexus_standalone_activity/README.md
@@ -0,0 +1,59 @@
+# Nexus operation backed by a standalone Activity
+
+This sample shows how to implement a `TemporalOperationHandler` that starts a
+standalone Activity as the backing execution for a Nexus operation. When the Activity
+finishes, Temporal delivers its result to the Nexus caller. The default handler
+cancellation implementation also forwards Nexus cancellation to the Activity.
+
+The APIs used by this sample are experimental and may change incompatibly.
+
+### Sample structure
+
+- [service.py](./service.py) defines the Nexus service shared by caller and handler.
+- [activity.py](./activity.py) defines the standalone Activity.
+- [handler.py](./handler.py) implements `TemporalOperationHandler.start_operation`.
+- [worker.py](./worker.py) hosts the Nexus handler and Activity.
+- [starter.py](./starter.py) executes the Nexus operation from client code.
+
+## Run locally
+
+This sample requires the [Temporal dev server build that supports standalone Nexus operations](https://docs.temporal.io/standalone-nexus-operation#temporal-cli-support) and Activity
+callbacks enabled.
+
+1. Start the server with caller and handler namespaces:
+
+   ```bash
+   ./temporal server start-dev \
+     --dynamic-config-value activity.enableCallbacks=true \
+     --namespace nexus-standalone-activity-caller \
+     --namespace nexus-standalone-activity-handler
+   ```
+
+2. Create an endpoint targeting the handler namespace and task queue:
+
+   ```bash
+   ./temporal operator nexus endpoint create \
+     --name nexus-standalone-activity-endpoint \
+     --target-namespace nexus-standalone-activity-handler \
+     --target-task-queue nexus-standalone-activity-handler
+   ```
+
+3. Start the handler Worker:
+
+   ```bash
+   TEMPORAL_NAMESPACE=nexus-standalone-activity-handler \
+     uv run nexus_standalone_activity/worker.py
+   ```
+
+4. Execute the operation from the caller namespace:
+
+   ```bash
+   TEMPORAL_NAMESPACE=nexus-standalone-activity-caller \
+     uv run nexus_standalone_activity/starter.py
+   ```
+
+Expected output:
+
+```text
+Hello, World!
+```
diff --git a/nexus_standalone_activity/__init__.py b/nexus_standalone_activity/__init__.py
new file mode 100644
index 00000000..6dca48d1
--- /dev/null
+++ b/nexus_standalone_activity/__init__.py
@@ -0,0 +1 @@
+"""Nexus operation backed by a standalone Activity sample."""
diff --git a/nexus_standalone_activity/activity.py b/nexus_standalone_activity/activity.py
new file mode 100644
index 00000000..a2ed8a50
--- /dev/null
+++ b/nexus_standalone_activity/activity.py
@@ -0,0 +1,10 @@
+"""Activity used as the backing execution for the Nexus operation."""
+
+from temporalio import activity
+
+from nexus_standalone_activity.service import GreetingInput, GreetingOutput
+
+
+@activity.defn
+async def create_greeting(input: GreetingInput) -> GreetingOutput:
+    return GreetingOutput(message=f"Hello, {input.name}!")
diff --git a/nexus_standalone_activity/handler.py b/nexus_standalone_activity/handler.py
new file mode 100644
index 00000000..960d75d0
--- /dev/null
+++ b/nexus_standalone_activity/handler.py
@@ -0,0 +1,36 @@
+"""Temporal operation handler that starts a standalone Activity."""
+
+from datetime import timedelta
+
+import nexusrpc.handler
+from temporalio import nexus
+
+from nexus_standalone_activity.activity import create_greeting
+from nexus_standalone_activity.service import (
+    GreetingInput,
+    GreetingOutput,
+    GreetingService,
+)
+
+
+def get_activity_id(input: GreetingInput) -> str:
+    return f"greeting-{input.name}"
+
+
+@nexusrpc.handler.service_handler(service=GreetingService)
+class GreetingServiceHandler:
+    @nexus.temporal_operation
+    async def greet(
+        self,
+        _ctx: nexus.TemporalStartOperationContext,
+        client: nexus.TemporalNexusClient,
+        input: GreetingInput,
+    ) -> nexus.TemporalOperationResult[GreetingOutput]:
+        # The standalone Activity becomes the asynchronous backing execution for
+        # this Nexus operation. Omitting task_queue uses the Nexus Worker's queue.
+        return await client.start_activity(
+            create_greeting,
+            input,
+            id=get_activity_id(input),
+            start_to_close_timeout=timedelta(seconds=10),
+        )
diff --git a/nexus_standalone_activity/service.py b/nexus_standalone_activity/service.py
new file mode 100644
index 00000000..ad3dad25
--- /dev/null
+++ b/nexus_standalone_activity/service.py
@@ -0,0 +1,20 @@
+"""Nexus service definition shared by the caller and handler."""
+
+from dataclasses import dataclass
+
+import nexusrpc
+
+
+@dataclass
+class GreetingInput:
+    name: str
+
+
+@dataclass
+class GreetingOutput:
+    message: str
+
+
+@nexusrpc.service
+class GreetingService:
+    greet: nexusrpc.Operation[GreetingInput, GreetingOutput]
diff --git a/nexus_standalone_activity/starter.py b/nexus_standalone_activity/starter.py
new file mode 100644
index 00000000..1db47e11
--- /dev/null
+++ b/nexus_standalone_activity/starter.py
@@ -0,0 +1,34 @@
+"""Client that executes the activity-backed Nexus operation."""
+
+import asyncio
+import uuid
+from datetime import timedelta
+
+from temporalio.client import Client
+from temporalio.envconfig import ClientConfig
+
+from nexus_standalone_activity.service import GreetingInput, GreetingService
+
+ENDPOINT_NAME = "nexus-standalone-activity-endpoint"
+
+
+async def main() -> None:
+    config = ClientConfig.load_client_connect_config()
+    _ = config.setdefault("target_host", "localhost:7233")
+    client = await Client.connect(**config)
+
+    nexus_client = client.create_nexus_client(
+        service=GreetingService,
+        endpoint=ENDPOINT_NAME,
+    )
+    result = await nexus_client.execute_operation(
+        GreetingService.greet,
+        GreetingInput(name="World"),
+        id=f"greeting-{uuid.uuid4()}",
+        schedule_to_close_timeout=timedelta(seconds=10),
+    )
+    print(result.message)
+
+
+if __name__ == "__main__":
+    asyncio.run(main())
diff --git a/nexus_standalone_activity/worker.py b/nexus_standalone_activity/worker.py
new file mode 100644
index 00000000..e4a15a0f
--- /dev/null
+++ b/nexus_standalone_activity/worker.py
@@ -0,0 +1,41 @@
+"""Worker hosting the Nexus handler and its standalone Activity."""
+
+import asyncio
+import logging
+
+from temporalio.client import Client
+from temporalio.envconfig import ClientConfig
+from temporalio.worker import Worker
+
+from nexus_standalone_activity.activity import create_greeting
+from nexus_standalone_activity.handler import GreetingServiceHandler
+
+TASK_QUEUE = "nexus-standalone-activity-handler"
+
+interrupt_event = asyncio.Event()
+
+
+async def main() -> None:
+    logging.basicConfig(level=logging.INFO)
+
+    config = ClientConfig.load_client_connect_config()
+    _ = config.setdefault("target_host", "localhost:7233")
+    client = await Client.connect(**config)
+
+    async with Worker(
+        client,
+        task_queue=TASK_QUEUE,
+        activities=[create_greeting],
+        nexus_service_handlers=[GreetingServiceHandler()],
+    ):
+        logging.info("Worker started, ctrl+c to exit")
+        _ = await interrupt_event.wait()
+
+
+if __name__ == "__main__":
+    loop = asyncio.new_event_loop()
+    try:
+        loop.run_until_complete(main())
+    except KeyboardInterrupt:
+        interrupt_event.set()
+        loop.run_until_complete(loop.shutdown_asyncgens())
diff --git a/tests/conftest.py b/tests/conftest.py
index b857e0d9..7f7fe066 100644
--- a/tests/conftest.py
+++ b/tests/conftest.py
@@ -42,6 +42,10 @@ async def env(request) -> AsyncGenerator[WorkflowEnvironment, None]:
     env_type = request.config.getoption("--workflow-environment")
     if env_type == "local":
         env = await WorkflowEnvironment.start_local(
+            dev_server_extra_args=[
+                "--dynamic-config-value",
+                "activity.enableCallbacks=true",
+            ],
             dev_server_download_version="v1.7.4-standalone-nexus-operations",
         )
     elif env_type == "time-skipping":
diff --git a/tests/nexus_standalone_activity/__init__.py b/tests/nexus_standalone_activity/__init__.py
new file mode 100644
index 00000000..7d425474
--- /dev/null
+++ b/tests/nexus_standalone_activity/__init__.py
@@ -0,0 +1 @@
+"""Tests for the Nexus standalone Activity sample."""
diff --git a/tests/nexus_standalone_activity/nexus_standalone_activity_test.py b/tests/nexus_standalone_activity/nexus_standalone_activity_test.py
new file mode 100644
index 00000000..e146c960
--- /dev/null
+++ b/tests/nexus_standalone_activity/nexus_standalone_activity_test.py
@@ -0,0 +1,57 @@
+import uuid
+from datetime import timedelta
+
+import pytest
+from temporalio.client import Client
+from temporalio.testing import WorkflowEnvironment
+from temporalio.worker import Worker
+
+from nexus_standalone_activity.activity import create_greeting
+from nexus_standalone_activity.handler import GreetingServiceHandler
+from nexus_standalone_activity.service import (
+    GreetingInput,
+    GreetingOutput,
+    GreetingService,
+)
+from nexus_standalone_activity.worker import TASK_QUEUE
+from tests.helpers.nexus import create_nexus_endpoint, delete_nexus_endpoint
+
+
+async def test_nexus_operation_backed_by_standalone_activity(
+    client: Client, env: WorkflowEnvironment
+) -> None:
+    if env.supports_time_skipping:
+        pytest.skip("Time-skipping server does not support standalone Nexus operations")
+
+    endpoint_name = f"test-nexus-standalone-activity-{uuid.uuid4()}"
+    create_response = await create_nexus_endpoint(
+        name=endpoint_name,
+        task_queue=TASK_QUEUE,
+        client=client,
+    )
+    try:
+        async with Worker(
+            client,
+            task_queue=TASK_QUEUE,
+            activities=[create_greeting],
+            nexus_service_handlers=[GreetingServiceHandler()],
+        ):
+            nexus_client = client.create_nexus_client(
+                service=GreetingService,
+                endpoint=endpoint_name,
+            )
+            result = await nexus_client.execute_operation(
+                GreetingService.greet,
+                GreetingInput(name="Test"),
+                id=str(uuid.uuid4()),
+                schedule_to_close_timeout=timedelta(seconds=10),
+            )
+
+            assert isinstance(result, GreetingOutput)
+            assert result.message == "Hello, Test!"
+    finally:
+        _ = await delete_nexus_endpoint(
+            id=create_response.endpoint.id,
+            version=create_response.endpoint.version,
+            client=client,
+        )